C8031

N⁶-シクロペンチルアデノシン

solid

• 別名: CPA
• 実験式（ヒル表記法）: C₁₅H₂₁N₅O₄
• CAS番号: 41552-82-3
• 分子量: 335.36
• MDL番号: MFCD00036845
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277686
• NACRES: NA.77

特性

• 形状: solid
• 品質水準: 200
• 色: white to off-white
• 溶解性: H₂O: 1.7 mg/mL; 0.1 M HCl: 12 mg/mL; DMSO: 23 mg/mL
• 保管温度: 2-8°C
• SMILES記法: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCC4)ncnc23
• InChI: 1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1
• InChI Key: SQMWSBKSHWARHU-SDBHATRESA-N
• 遺伝子情報: human ... ADORA1(134) , ADORA2A(135) , ADORA3(140) ; mouse ... Adora1(11539) ; rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)

詳細

アプリケーション

N⁶-Cyclopentyladenosine has also been used to study its effect on p53 and caspase 3, 8, and 9 expression and apoptosis rate in MCF-7 breast cancer cell line.

N⁶-Cyclopentyladenosine has been used to study its effect on the cavernosal smooth muscle cells from lean and db/db (obesity and type II diabetes caused by a leptin receptor mutation) mice.

生物化学的／生理学的作用

N⁶-Cyclopentyladenosine (CPA) is an adenosine derivative and a potent A1 adenosine receptor agonist. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.

N⁶-Cyclopentyladenosine also exhibits analgesic effect against acute, arthritis-induced and neuropathic pain.

特徴および利点

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

物理的形状

吸湿性の固体

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)