E2764

Anti-Endothelin Receptor B antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 別名: Anti-ET-B, Anti-ET-Specific Endothelin Receptor
• MDL番号: MFCD02677992
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IHC (p); WB CL
• クローン: polyclonal
• 化学種の反応性: rat
• citations: 11
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100; western blot (chemiluminescent): 1:200

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 化学種の反応性: rat
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100; western blot (chemiluminescent): 1:200
• UniProtアクセッション番号: P21451
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: rat ... Ednrb(50672)

詳細

詳細

Endothelin Receptor B (EDNRB) is a G-protein coupled receptor and that consists of seven transmembrane domains. EDNRB gene is located on the human chromosome at 13q22.3.

免疫原

synthetic peptide corresponding to amino acids 298-313 of rat endothelin receptor type B. The epitope is identical in all known vertebrate ET-B receptors

アプリケーション

Anti-Endothelin Receptor B antibody produced in rabbit has been used in immunohistochemistry (1:100).

生物化学的／生理学的作用

EDNRB Endothelin receptor type B (ETB) plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.

Mutations in the EDNRB gene are associated with Hirschsprung disease.

物理的形状

Lyophilized at 0.8 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335,H412
• 注意書き: P273 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable