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リコンビナント
expressed in E. coli
品質水準
詳細
contains a C-terminal hexahistidine tag
アッセイ
≥90% (SDS-PAGE)
フォーム
liquid
比活性
≥0.4 μmol/mg protein
分子量
~37 kDa
NCBIアクセッション番号
輸送温度
dry ice
保管温度
−70°C
遺伝子情報
human ... AKR1C3(8644)
アプリケーション
Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .
生物化学的／生理学的作用
PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .
単位の定義
1 unitは、50 mM KPO4(pH 7.2、250 μM NADPHおよび25 μM 9,10-フェナントレンキノン含有)中で、37°C、1分間に、1 μmolのNADPを生成するために必要な酵素量と定義されています。
保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
F7807-VAR:
F7807-BULK:
F7807-50UG-PW:
F7807-50UG:
最新バージョンのいずれかを選択してください：
Kikuko Watanabe
Prostaglandins & other lipid mediators, 68-69, 401-407 (2002-11-16)
Prostaglandin (PG) F2 is synthesized via three pathways from PGE2, PGD2, or PGH2 by PGE 9-ketoreductase, PGD 11-ketoreductase, or PGH 9-, 11-endoperoxide reductase, respectively. The enzymological and molecular biological properties of these enzymes have been reported in work over the
Dominika Slonina et al.
Prostaglandins & other lipid mediators, 90(3-4), 69-75 (2009-09-15)
The aim was to study whether bovine myometrial cells have an enzymatic system able to produce prostaglandins (PGs) and whether PGs synthesis is regulated by steroids in a similar manner as endometrial cells. In Experiment 1, immunohistochemical studies localized proteins
Mariusz Pawel Kowalewski et al.
Animal reproduction science, 116(1-2), 129-138 (2009-01-24)
In nonpregnant and pregnant dogs the corpora lutea (CL) are the only source of progesterone (P4) which shows an almost identical secretion pattern until the rapid decrease of P4 prior to parturition. For the nonpregnant dog clear evidence has been
Marta Wasielak et al.
Reproduction, fertility, and development, 21(5), 709-717 (2009-06-03)
The present study was conducted to evaluate the effect of the conceptus on uterine prostaglandin-F2alpha (PGF2alpha) and prostaglandin-E2 (PGE2) release and the expression of prostaglandin synthase enzymes during the periimplantation period in the pig. A surgically generated model with conceptuses
R J Phillips et al.
Molecular human reproduction, 17(1), 1-13 (2010-07-03)
Prostaglandins (PGs) are important factors in the physiology of human parturition and the control of uterine contractility. We have characterized the expression of 15 genes from all stages of the PG pathway in human pregnant and non-pregnant (NP) myometrium and
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