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詳細
IgM is a class of antibodies containing a pentamer of five IgG equivalents with 10 Fab fragments, joined by a single cross-linking peptide (J-chain). It constitutes 15% of the normal adult immunoglobulins.
特異性
The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, IgM, Bence Jones kappa, and lambda myeloma proteins.
アプリケーション
Anti-Human IgM (μ-chain specific) antibody produced in rabbit was used as secondary antibody in immunoblotting and indirect ELISA.
生物化学的／生理学的作用
IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM is an initial immunoglobulin produced in the developing fetus as a result of the immune response during the second trimester of pregnancy. It is then substituted by IgG. Therefore, the diagnosis of specific antibodies of the IgM class is useful in detecting chronic infections. IgM is essential for the fetal and neonatal host defense system. IgM cannot cross the placenta. Hence, the presence of IgM might indicate an intrauterine viral infection. IgM antibodies are responsible for the agglutination of red blood cells in mismatched blood transfusions. The level of IgM may vary with the status of disease or infection.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative
保管および安定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots at –20 °C. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
I0140-2ML:
I0140-VAR:
I0140-BULK:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Immunology of the Fetus and Newborn
Avery's Diseases of the Newborn, 445-467 null
Overview of the Immune Response
The Journal of Allergy and Clinical Immunology null
J Raper et al.
Infection and immunity, 67(4), 1910-1916 (1999-03-20)
Natural resistance of humans to the cattle pathogen Trypanosoma brucei brucei has been attributed to the presence in human serum of nonimmune factors that lyse the parasite. Normal human serum contains two trypanosome lytic factors (TLFs). TLF1 is a 500-kDa
E J Wiersma et al.
Journal of immunology (Baltimore, Md. : 1950), 160(12), 5979-5989 (1998-06-24)
Previous studies have discerned two forms of polymeric mouse IgM: moderately cytolytic (complement-activating) pentamer, which contains J chain, and highly cytolytic hexamer, which lacks J chain. To investigate the relationships among polymeric structure, J chain content, and cytolytic activity, we
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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