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About This Item
実験式（ヒル表記法）:
C9H8N2O2
CAS番号:
分子量:
176.17
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
NACRES:
NA.77
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品質水準
アッセイ
≥97% (HPLC)
フォーム
solid
色
off-white
溶解性
DMSO: soluble >20 mg/mL
H2O: insoluble
保管温度
−20°C
SMILES記法
CC1=Nc2c(O)cccc2C(=O)N1
InChI
1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)
InChI Key
YJDAOHJWLUNFLX-UHFFFAOYSA-N
遺伝子情報
mouse ... Parp2(11546)
生物化学的／生理学的作用
NU-1025 is a PARP inhibitor.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
N7287-5MG:
N7287-VAR:
N7287-BULK:
Quanju Zhao et al.
Journal of immunology (Baltimore, Md. : 1950), 198(7), 2935-2942 (2017-02-22)
IL-12 and IL-23 are important host defense factors produced by APCs against certain intracellular and extracellular pathogens. Their dysregulation has also been implicated in several autoimmune diseases. The nucleotide polymorphism in the promoter region of Il12b (rs41292470 consisting of the
David Zada et al.
Molecular cell, 81(24), 4979-4993 (2021-11-20)
The characteristics of the sleep drivers and the mechanisms through which sleep relieves the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA damage levels increase during wakefulness and decrease during sleep. Here, we show that 6 h
Evangelos Koustas et al.
Journal of cellular and molecular medicine, 24(18), 10420-10431 (2020-07-21)
Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. Activation of c-MET increases tumour cell survival through the initiation of the DNA damage repair pathway. PARP is an essential key in the
Michael M Murata et al.
Molecular biology of the cell, 30(20), 2584-2597 (2019-08-08)
DNA damage signaling is critical for the maintenance of genome integrity and cell fate decision. Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor rapidly activated in a damage dose- and complexity-dependent manner playing a critical role in the initial
Yang Sun et al.
American journal of respiratory cell and molecular biology, 51(6), 738-749 (2014-05-31)
Lymphangioleiomyomatosis (LAM) is a female-predominant cystic lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis complex 2 (TSC2) mutations and mammalian target of rapamycin (mTOR) complex (mTORC) 1 activation. Clinical response to the mTORC1
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