S4072

抗Sirt3抗体 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗SIR2L3抗体, 抗サーチュイン(silent mating type information regulation2ホモログ) 3 (S. cerevisiae) 抗体
• MDL番号: MFCD07784765
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IF; WB
• クローン: polyclonal
• 化学種の反応性: human
• citations: 14
• テクニック: indirect immunofluorescence: suitable; western blot: 2.5-5 μg/mL using human HepG2 cells

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~28 kDa
• 化学種の反応性: human
• テクニック: indirect immunofluorescence: suitable; western blot: 2.5-5 μg/mL using human HepG2 cells
• UniProtアクセッション番号: Q9NTG7
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SIRT3(23410)

詳細

詳細

Sirtuin 3 (Sirt3) is an NAD-dependent deacetylase localized to the mitochondrial matrix. SIRT3 encodes a 44 kDa full length form and a N-terminal 142 amino acids truncated form. It is mapped to human chromosome 11p15.5.

免疫原

ヒトSIRT3のアミノ酸384~399に相当する合成ペプチド (N末端システイン付加) のKLH結合体。

アプリケーション

Anti-Sirt3 antibody produced in rabbit has been used in western blotting.

生物化学的／生理学的作用

Sirtuin 3 (Sirt3) is mainly a nuclear protein that transfers to the mitochondria during cellular stress. In humans, Sirt3 deacetylates and activates the mitochondrial enzyme acetyl-CoA synthetase 1 (AceCS2). Sirt3 is implicated in regulating mitochondrial function and thermogenesis in brown adipocytes. Its levels have been shown to correlate with extended life span. Increased levels of Sirt3 were associated with node positive breast cancer.

物理的形状

0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)