S7701
Sorbinil
≥98% (HPLC)
別名:
(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione, (4S)-6-Fluoro-2,3-dihydro-spiro[4H-1-benzopyran-4,4′-imidazolidine]-2′,5′-dione, CP 45634
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About This Item
実験式（ヒル表記法）:
C11H9FN2O3
CAS番号:
分子量:
236.20
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
NACRES:
NA.77
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品質水準
アッセイ
≥98% (HPLC)
形状
powder
光学活性
[α]/D +50 to +60°, c = 1 in methanol
色
white to off-white
溶解性
DMSO: ≥20 mg/mL
保管温度
2-8°C
SMILES記法
Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
InChI
1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
InChI Key
LXANPKRCLVQAOG-NSHDSACASA-N
アプリケーション
Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
Sorbinil may be used in cell signaling and neuroscience studies.
生物化学的／生理学的作用
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
Sorbinil is an inhibitor of Aldose Reductase (AR). AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.
特徴および利点
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
免責事項
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Eleonora Peroni et al.
Antioxidants (Basel, Switzerland), 9(5) (2020-05-10)
One of the consequences of the increased level of oxidative stress that often characterizes the cancer cell environment is the abnormal generation of lipid peroxidation products, above all 4-hydroxynonenal. The contribution of this aldehyde to the pathogenesis of several diseases
Antonella Del-Corso et al.
PloS one, 8(9), e74076-e74076 (2013-09-11)
Aldose reductase (AR) is an NADPH-dependent reductase, which acts on a variety of hydrophilic as well as hydrophobic aldehydes. It is currently defined as the first enzyme in the so-called polyol pathway, in which glucose is transformed into sorbitol by
Sonia Manzanaro et al.
Journal of natural products, 69(10), 1485-1487 (2006-10-28)
Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds
Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.
Sally A Madsen-Bouterse et al.
Reviews in endocrine & metabolic disorders, 9(4), 315-327 (2008-07-26)
Retinopathy is one of the most severe ocular complications of diabetes and is a leading cause of acquired blindness in young adults. The cellular components of the retina are highly coordinated but very susceptible to the hyperglycemic environment. The microvasculature
R J Young et al.
Diabetes, 32(10), 938-942 (1983-10-01)
A double-blind, randomized, placebo-controlled cross-over trial of the aldose reductase inhibitor sorbinil was undertaken in 15 patients (age 35-68 yr) with chronic painful diabetic neuropathy. Treatment was evaluated by subjective pain responses, clinical examination, vibration perception threshold, motor and sensory
資料
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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