SAB2500438

抗G6PD(アミノ酸308-320)抗体 ヤギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗G6PD1抗体, 抗グルコース-6-リン酸デヒドロゲナーゼ抗体
• MDL番号: MFCD00162329
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA (i); IHC; WB
• クローン: polyclonal
• 化学種の反応性: canine, rat, mouse, human
• citations: 5
• テクニック: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable

特性

• 由来生物: goat
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: canine, rat, mouse, human
• テクニック: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProtアクセッション番号: P11413
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... G6PD(2539)

詳細

詳細

The gene encoding G6PD (glucose-6-phosphate dehydrogenase) is mapped to human chromosome Xq28 and spans 16.2 kb. One G6PD monomer is composed of 515 amino acids with a predicted molecular weight of 59,256 Da. The active enzyme exists as a dimer and contains an NADP molecule tightly bound to it.

免疫原

NP_000393.4; NP_001035810.1によるタンパク質配列の内部領域に由来するペプチド(C-STNSDDVRDEKVK)。

生物化学的／生理学的作用

G6PD (glucose-6-phosphate dehydrogenase) enzyme catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone, reducing NADP to NADPH. It therefore, catalyzes the first step of hexose monophosphate pathway (HMP). As it oxidizes glucose-6-phosphate, it confers protection against oxidative damage in erythrocytes. Its deficiency is highly heterogeneous, with around 190 variants being reported. The deficiency of G6PD was discovered while studying hemolytic anemia. G6PD also results in hereditary nonspherocytic hemolytic anemia.

特徴および利点

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物理的形状

0.5 mg/mL Tris緩衝生理食塩水(0.5% BSA, 0.02%アジ化ナトリウム含有)。

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable