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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
交差性
human, rat, mouse
テクニック
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... RIPK1(8737)
詳細
Receptor interacting serine/threonine kinase 1 (RIPK1) gene is located at 6p25.2 on the human chromosome. It belongs to the RIPK family. RIPK1 is a necroptosis regulatory protein. It is made up of N-terminal kinase domain, a RIP homotypic interaction motif and its C-terminal contains the death domain.
免疫原
RIPK1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human RIPK1.
アプリケーション
Anti-RIPK1 antibody produced in rabbit has been used in:
- western blotting
- immunocytochemistry
- immunofluorescence
生物化学的／生理学的作用
Receptor interacting serine/threonine kinase 1 (RIPK1) is involved in inflammatory signaling and prosurvival. It is also involved in regulating the caspase-8-mediated apoptosis. RIPK1 plays a role in activating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein (MAP) kinases. Mutations in this gene is associated with impaired innate and adaptive immunity. It also leads to very early onset inflammatory bowel diseases (VEO-IBDs).
Receptor interacting serine/threonine kinase 1 (RIPK1) modulates cell survival and death. It also has a role in inflammation.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
関連事項
The action of this antibody can be blocked using blocking peptide SBP3500420.
物理的形状
PBS（0.02％ アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB3500420-100UG:
最新バージョンのいずれかを選択してください：
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
Rickard J A, et al.
Cell, 157(5), 1175-1188 (2014)
Nunzio Antonio Cacciola et al.
International journal of molecular sciences, 23(15) (2022-08-13)
Recent pharmacological research on milk whey, a byproduct of the dairy industry, has identified several therapeutic properties that could be exploited in modern medicine. In the present study, we investigated the anticancer effects of whey from Mediterranean buffalo (Bubalus bubalis)
Tauroursodeoxycholic acid protects nucleus pulposus cells from compression-induced apoptosis and necroptosis via inhibiting endoplasmic reticulum stress
Wang W, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2018(3), 493-499 (2018)
Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases
Li Y, et al.
Proceedings of the National Academy of Sciences, 116(3), 970-975 (2019)
Receptor interacting protein kinases-dependent necroptosis as a new, potent mechanism for elimination of the endothelial cells during luteolysis in cow
Hojo T, et al.
Theriogenology, 128(3), 193-200 (2019)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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