SAB4200018

モノクロナール抗オステオポンチン マウス宿主抗体

clone OPN46, purified from hybridoma cell culture

• 別名: 初期Tリンパ球活性化タンパク質1(ETA1)抗体, 抗BNSP抗体, 抗OPN抗体, 抗SPP1抗体, 抗ウロポンチン抗体, 抗分泌性ホスホプロテイン1抗体, 抗尿路結石タンパク質抗体, 抗骨シアロタンパク質1抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified from hybridoma cell culture
• 抗体製品タイプ: primary antibodies
• クローン: OPN46, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~60 kDa
• 化学種の反応性: human, mouse, monkey, rat, canine
• 濃度: ~1.0 mg/mL
• テクニック: western blot: 5-10 μg/mL using HepG2 cells extract
• アイソタイプ: IgG1
• UniProtアクセッション番号: P10451
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SPP1(6696)

詳細

詳細

Monoclonal Anti-Osteopontin (mouse IgG1 isotype) is derived from the hybridoma OPN46 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids of human osteopontin. Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein which serves as a cytokine and as an extracellular matrix molecule. It is produced by multiple tissues in the body and is most abundant in bone.

アプリケーション

Monoclonal Anti-Osteopontin antibody produced in mouse may be used in immunoblotting.

生物化学的／生理学的作用

Osteopontin (OPN) synthesized in cancer cells is essentail for growth, progression and metastasis of cancer. In tuomr cells OPN is highly expressed The structural features of OPN differ between normal and tumor cells Three osteopontin splice variant transcripts have been found to be expressed in invasive, but not in non-invasive breast tumor cell lines. Osteopontin-b lacks exon 5 and osteopontin-c lacks exon 4. The shortest splice variant, osteopontin-c may support breast tumor progression by conveying anchorage independence and inducing oxidoreductases expression. It was also suggested as a diagnostic and prognostic breast cancer marker.

物理的形状

0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable