SAB4200541

Anti-ADAR1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 別名: 抗DRADA抗体, 抗IFI-4抗体, 抗K88DSRBP抗体, 抗P136抗体
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IF; IP; WB
• クローン: polyclonal
• 化学種の反応性: human
• citations: 8
• テクニック: immunoprecipitation (IP): 10-20 μg using lysates of human HepG2 or HEK-293T cells.; indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells.; western blot: 2-4 μg/mL using whole extracts of human HEK-293T cells.

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~110 kDa
• 化学種の反応性: human
• 濃度: ~1.0 mg/mL
• テクニック: immunoprecipitation (IP): 10-20 μg using lysates of human HepG2 or HEK-293T cells.; indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells.; western blot: 2-4 μg/mL using whole extracts of human HEK-293T cells.
• UniProtアクセッション番号: P55265
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: bovine ... ADAR(505134) ; human ... ADAR(103) ; mouse ... Adar(56417) ; rat ... Adar(81635)

詳細

詳細

Adenosine deaminase that acts in RNA (ADAR) exists in two isoforms namely, ADAR1 and ADAR2, in mammals. Both the isoforms are expressed in variety of tissues but in general, the pre-mRNA being edited represents receptors of the central nervous systems. ADAR1 has several isoforms which include the full length ADAR1 (150 kDa) and two functionally active short isoforms (80 and 110 kDa).

免疫原

synthetic peptide corresponding to an internal s of human ADAR1, conjugated to KLH. The corresponding sequence is identical in mouse, rat, bovine, pig and monkey.

アプリケーション

Anti-ADAR1 antibody produced in rabbit has been used in

• immunoblotting
• immunoprecipitation
• immunofluorescence

生物化学的／生理学的作用

Adenosine deaminase that acts in RNA 1 (ADAR1) play an important role in A-to-I RNA editing. In addition, it is also implicated in differentiating cells of embryo and adult tissues, facilitating cell survival and permitting their further differentiation and maturation. Its role in embryonic development is specifically observed within the hematopoietic lineage as well as in adult hematopoietic progenitor cells (HPCs). ADAR1 plays a key role in hematopoietic stem cell maintenance. It also block interferon signaling, that might help organisms to fight against the harmful effects of interferon activation linked with various diseases, such as chronic inflammation, autoimmune disorders and cancer.

物理的形状

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable