SAB4300670

Anti-phospho-SP1 (pThr⁷³⁹) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-Sp1 transcription factor, Anti-TSFP1
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: ~90 kDa
• 化学種の反応性: human, mouse, rat
• 濃度: 1 mg/mL
• テクニック: western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (T-A-Tp-P-S)
• NCBIアクセッション番号: NM_138473.2
• UniProtアクセッション番号: P08047
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pThr739)
• 遺伝子情報: human ... SP1(6667)

詳細

詳細

Specific protein 1 (Sp1) is a transcription regulator that has a transactivation domain at the N-terminus and a DNA-binding domain at the C-terminus, that contain three zinc fingers (ZF). It belongs to transcription factor family and is located on chromosome 12q13.

免疫原

Peptide sequence around phosphorylation site of threonine 739 (T-A-Tp-P-S), according to the protein NP_612482.2

アプリケーション

Anti-phospho-SP1 (pThr739) antibody has been used in immunohistochemistry.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

生物化学的／生理学的作用

Specific protein 1 (Sp1) controls the up- and down-regulation of hCtr1 (human high-affinity copper transporter 1). It controls the expression of several genes that participates in differentiation, cell cycle and oncogenesis. It has the ability to bind GC/GT‐rich promoter elements with the help of C(2)H(2)‐type zinc fingers at the C‐terminal domain.

特徴および利点

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ターゲットの説明

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable