SAB4301526

Anti-phospho-mTOR (pSer²⁴⁸¹) antibody produced in rabbit

affinity isolated antibody

• 別名: FRAP, FRAP1, FRAP2, RAFT1, RAPT1
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 288 kDa
• 化学種の反応性: rat, human, mouse
• 濃度: 1.0 mg/mL
• テクニック: western blot: 1:500-1:1000 (Cell Lysate)
• アイソタイプ: IgG
• アクセッション番号: NP_004949.1
• UniProtアクセッション番号: P42345
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pSer2481)
• 遺伝子情報: human ... MTOR(2475)

詳細

詳細

Mechanistic target of rapamycin kinase (MTOR) is a serine/threonine kinase. mTOR belongs to the family of phosphatidylinositol kinase-related kinase (PIKK). mTOR exists as two different complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). In human chromosome, the gene MTOR is localized on 1p36.22.

特異性

The antibody detects endogenous level of mTOR only when phosphorylated at Serine 2481.

免疫原

Peptide sequence around phosphorylation site of Serine 2481(I-H-S(p)-F-I) derived from Human mTOR.

アプリケーション

Anti-phospho-mTOR (pSer2481) antibody produced in rabbit has been used in western blot analysis.

生物化学的／生理学的作用

Mechanistic target of rapamycin kinase (MTOR) recognizes various intracellular and extracellular signals and processes them to regulate cell growth, metabolism, proliferation and survival. mTOR is also involved in mitochondrial respiration by activating oxidative phosphorylation. Deregulation of mTOR phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) complex signalling pathway, leads to leukaemogenesis. Mutations leading to aberrant expression of mTOR causes cancer cachexia. mTOR plays a key role in synaptic plasticity and autophagy. Polymorphism of mTOR is associated with brain malformation and various neuropsychiatric disorders like brain ischemia, autism, epilepsy, schizophrenia etc. mTOR is a key regulator of anabolic and catabolic processes. mTOR is activated by insulin or insulin like growth factor 1 (IGF1) and regulate PI3K/Akt/mTOR/tuberous sclerosis (TSC)/the small GTPase (guanidine triphosphatase) Ras (rat sarcoma) homologue enriched in brain (RHEB) signalling pathway. mTOR is a key regulator of lipid biogenesis by influencing lipogenic genes like sterol regulatory element-binding protein 1 (SREBP1). Dysregulation of mTOR is associated with type 2 diabetes and obesity.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable