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Merck

SAB4501665

Sigma-Aldrich

Anti-Keratin 18 antibody produced in rabbit

affinity isolated antibody

別名:

CK 18, CK18, CYK18, Cytokeratin endo B, K18

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41
結合体:
unconjugated
application:
ELISA
IF
IHC
WB
クローン:
polyclonal
化学種の反応性:
mouse, rat, human
citations:
7
テクニック:
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

フォーム

buffered aqueous solution

分子量

antigen 48 kDa

化学種の反応性

mouse, rat, human

濃度

~1 mg/mL

テクニック

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... KRT18(3875)

詳細

Anti-Keratin 18 antibody detects endogenous levels of total Keratin 18 protein.
Keratin 18/cytokeratin 18 (CK18) is a structural protein. It is present in single-layer epithelia. It is located on human chromosome 12q13.

免疫原

The antiserum was produced against synthesized peptide derived from human Keratin 18.

Immunogen Range: 381-430

生物化学的/生理学的作用

Keratins help to maintain the structural integrity. They also control Fas‐mediated apoptosis and regulate cell size and protein synthesis. Keratin 18 plays a major role in the development of lung cancer. It acts as a therapeutic target for non-small cell lung cancer (NSCLC).

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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Lot/Batch Number

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Diptendu Chatterjee et al.
European heart journal, 41(30), 2878-2890 (2020-06-14)
Brugada syndrome (BrS) is characterized by a unique electrocardiogram (ECG) pattern and life-threatening arrhythmias. However, the Type 1 Brugada ECG pattern is often transient, and a genetic cause is only identified in <25% of patients. We sought to identify an
Lucy Pilcher et al.
Stem cells international, 2024, 8601360-8601360 (2024-01-19)
The epicardium is a layer of mesothelial cells that covers the surface of the heart. During development, epicardial cells undergo epithelial-to-mesenchymal transition (EMT) to form multipotent precursors that migrate into the heart and contribute to the coronary vasculature by differentiating
Kasey Y C Lau et al.
Cell stem cell, 29(10), 1445-1458 (2022-09-10)
Several in vitro models have been developed to recapitulate mouse embryogenesis solely from embryonic stem cells (ESCs). Despite mimicking many aspects of early development, they fail to capture the interactions between embryonic and extraembryonic tissues. To overcome this difficulty, we have
Carlos A Pinzón-Arteaga et al.
Cell stem cell, 30(5), 611-616 (2023-05-06)
Understanding the mechanisms of blastocyst formation and implantation is critical for improving farm animal reproduction but is hampered by a limited supply of embryos. Here, we developed an efficient method to generate bovine blastocyst-like structures (termed blastoids) via assembling bovine
Cytokeratin 18 knockdown decreases cell migration and increases chemosensitivity in non-small cell lung cancer
Zhang B, et al.
Journal of Cancer Research and Clinical Oncology, 142(12), 2479-2487 (2016)

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