おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 74 kDa
交差性
mouse, human, rat
濃度
~1 mg/mL
テクニック
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... LMNA(4000)
詳細
Lamin A/C (LMNA) gene codes for lamin A and C. Lamin A/C is a nuclear intermediate filament protein. LMNA gene is mapped to human chromosome 1q22. Anti-Lamin A Antibody detects endogenous levels of total Lamin A protein.
免疫原
The antiserum was produced against synthesized peptide derived from human Lamin A/C.
Immunogen Range: 361-410
Immunogen Range: 361-410
アプリケーション
Anti-Lamin A antibody produced in rabbit has been used in immunoblotting.
生物化学的／生理学的作用
Lamin A/C (LMNA) is involved in the structural organization of the nucleus. It modulates gene expression. It may play a role in osteoblastogenesis. Mutation in the LMNA gene is associated with muscle dystrophies, cardiomyopathies, lipodystrophies, and neuropathies. LMNA protein plays a vital role in cell cycle progression. It controls extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) and Wnt β-catenin pathway.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Halida P Widyastuti et al.
BMC medical genetics, 21(1), 152-152 (2020-07-24)
Intermediate filament proteins that construct the nuclear lamina of a cell include the Lamin A/C proteins encoded by the LMNA gene, and are implicated in fundamental processes such as nuclear structure, gene expression, and signal transduction. LMNA mutations predominantly affect
Anna Sowińska-Seidler et al.
Journal of applied genetics, 59(3), 281-289 (2018-05-31)
Craniosynostosis (CS) refers to the group of craniofacial malformations characterized by the premature closure of one or more cranial sutures. The disorder is clinically and genetically heterogeneous and occurs usually as an isolated trait, but can also be syndromic. In
Hin Chu et al.
The Journal of biological chemistry, 293(30), 11709-11726 (2018-06-12)
Coronavirus tropism is predominantly determined by the interaction between coronavirus spikes and the host receptors. In this regard, coronaviruses have evolved a complicated receptor-recognition system through their spike proteins. Spikes from highly related coronaviruses can recognize distinct receptors, whereas spikes
Lorenzo Bazzani et al.
Oncotarget, 9(19), 14939-14958 (2018-03-31)
Prostaglandin E2 (PGE2) contributes to tumor progression by promoting cancer cell growth, invasion and by creating a favorable pro-tumor microenvironment. PGE2 has been reported to transactivate and internalize into the nucleus receptor tyrosine kinases such as Epidermal growth factor receptor
Elena V Ignatieva et al.
Genes, 11(9) (2020-09-11)
Laminopathies are a family of monogenic multi-system diseases resulting from mutations in the LMNA gene which include a wide range of neuromuscular disorders. Although lamins are expressed in most types of differentiated cells, LMNA mutations selectively affect only specific tissues
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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