SAB4700168

Monoclonal Anti-CD36-FITC antibody produced in mouse

clone CB38, purified immunoglobulin, buffered aqueous solution

• 別名: Anti-GPIIIb
• UNSPSCコード: 12352203
• NACRES: NA.44

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: FITC conjugate
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: CB38, monoclonal
• 形状: buffered aqueous solution
• 化学種の反応性: human
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG1
• NCBIアクセッション番号: NM_000072.3
• UniProtアクセッション番号: P16671
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CD36(948)

詳細

詳細

Cluster of differentiation 36 (CD36) is an 88 kDa membrane transporter glycoprotein. It is also known as platelet glycoprotein IV or IIIb. CD36 is a class B scavenger receptor expressed in platelets, endothelial cells, adipocytes, skeletal muscle cells and monocytes/macrophages. In human chromosome, the gene CD36 is localized on 7q21.11. CD36 (fatty acid translocase, FAT) is an 85-113 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not follicular and B1 B cells, and it is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids.

特異性

The antibody CB38 reacts with CD36 (GPIIIb), a 85 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5.

免疫原

Human myeloid cells

アプリケーション

The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (0.4 mL) is sufficient for 100 tests.

生物化学的／生理学的作用

Cluster of differentiation 36 (CD36) is a receptor for various ligands and act as a signalling molecule. CD36 facilitates the uptake of fatty acids, cholesterol, cholesteryl esters, low and high density lipoproteins. CD36 is involved in fatty acid metabolism. Polymorphism associated with CD36 increases the free fatty acid levels in plasma leading to cardiovascular disease, and hypertension. Polymorphism in CD36 causes type 2 diabetes mellitus. CD36 is a high affinity receptor, which aids in dietary fat perception in the tongue. CD36 along with Toll like receptors (TLRs) aids in internalization of Plasmodium falciparum parasitized erythrocytes. Mutations leading to deficiency of CD36 increases the severity of malaria. CD36 is an inhibitor of lung cancer and the hypermethylation of CD36 leads to cancer progression. CD36, a receptor for thrombospondin. regulates ovarian angiogenesis. High expression of CD36 is implicated in polycystic ovarian syndrome (PCOS).

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

PBS（15 mM アジ化ナトリウム、安定化剤として0.2％ハイグレード プロテアーゼフリーBSA含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable