SAB4700480

Monoclonal Anti-CD45-FITC antibody produced in mouse

clone MEM-28, purified immunoglobulin, buffered aqueous solution

• 別名: 抗LCA抗体, 抗PTPRC抗体
• UNSPSCコード: 12352203
• NACRES: NA.43
• 結合体: FITC conjugate
• application: FACS
• クローン: MEM-28, monoclonal
• 化学種の反応性: human
• citations: 7
• テクニック: flow cytometry: suitable

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: FITC conjugate
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: MEM-28, monoclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: human
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG1
• NCBIアクセッション番号: NM_002838.3
• UniProtアクセッション番号: P08575
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PTPRC(5788)

詳細

詳細

The antibody MEM-28 reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets.

The cluster of differentiation 45 (CD45) gene is mapped to human chromosome 1q31.3-q32.1. It codes for a type I transmembrane protein and is expressed in nucleated hematopoietic cells along within its precursors. The protein consists of a varying extracellular domain and a highly conserved intracellular domain.

免疫原

Human thymocytes and T lymphocytes

アプリケーション

試薬は、100 μL全血または1e6細胞懸濁液につき20 μLの試薬を用いたヒト血液細胞のフローサイトメトリー解析用にデザインされています。バイアル（2 mL）の内容量は100回分です。

生物化学的／生理学的作用

Cluster of differentiation 45 (CD45) functions as a prototypic receptor and exhibits phosphatase activity. CD45 is implicated in the regulation of T-cell mediated B cell antigen receptor (BCR)-signaling. The encoded protein plays an essential role in antigen-stimulated proliferation of T lymphocytes and in thymic development. CD45 negatively regulates cytokine receptor signaling via suppressing JAK (Janus kinase) activity.

特徴および利点

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物理的形状

PBS（15 mM アジ化ナトリウム、安定化剤として0.2％ハイグレード プロテアーゼフリーBSA含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable