SML1061

PF-04856264

≥98% (HPLC)

• 別名: 3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide
• 実験式（ヒル表記法）: C₂₀H₁₅N₅O₃S₂
• CAS番号: 1235397-05-3
• 分子量: 437.49
• MDL番号: MFCD28124397
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825643
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to light brown
• 溶解性: DMSO: 10 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=S(C(C=C1)=CC(C#N)=C1OC2=CC=CC=C2C3=CC=NN3C)(NC4=NC=CS4)=O
• InChI: 1S/C20H15N5O3S2/c1-25-17(8-9-23-25)16-4-2-3-5-19(16)28-18-7-6-15(12-14(18)13-21)30(26,27)24-20-22-10-11-29-20/h2-12H,1H3,(H,22,24)
• InChI Key: MKSKJVIBSRUWSZ-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC₅₀ = 28 nM). PF-04856264 blocks mouse Nav1.7 (IC₅₀ = 131 nM) but has low potency against the rat Nav1.7 channel (IC₅₀ = 4.2 mM).

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable