SML1567

MCB-613

≥98% (HPLC)

• 別名: 4-Ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone
• 実験式（ヒル表記法）: C₂₀H₂₀N₂O
• CAS番号: 296792-62-6
• 分子量: 304.39
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: 2-8°C

詳細

詳細

MCB-613 (4-Ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone) belongs to the chalcone class of compounds. It is an anti-neoplastic compound.

アプリケーション

MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death.

生物化学的／生理学的作用

MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.

MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable