SML2813

UNC6934

≥98% (HPLC)

• 別名: 3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid cyclopropyl-[4-(pyrimidin-4-ylcarbamoyl)-benzyl]-amide
• 実験式（ヒル表記法）: C₂₄H₂₁N₅O₄
• CAS番号: 2561494-77-5
• 分子量: 443.45
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=CC=C(CN(C2CC2)C(C3=CC4=C(NC(CO4)=O)C=C3)=O)C=C1)NC5=CC=NC=N5
• InChI: 1S/C24H21N5O4/c30-22-13-33-20-11-17(5-8-19(20)27-22)24(32)29(18-6-7-18)12-15-1-3-16(4-2-15)23(31)28-21-9-10-25-14-26-21/h1-5,8-11,14,18H,6-7,12-13H2,(H,27,30)(H,25,26,28,31)

詳細

生物化学的／生理学的作用

SGC probe under development. UNC6934 is a potent and selective antagonist of histone-lysine N-methyltransferase NSD2-PWWP1 domain (Nuclear Receptor Binding SET Domain Protein 2 PWWP1 domain). UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable