SML3586

MU1700 dihydrochloride

≥98% (HPLC)

• 別名: 6-(4-(Piperazin-1-yl)phenyl)-3-(quinolin-4-yl)furo[3,2-b]pyridine dihydrochloride
• 実験式（ヒル表記法）: C₂₆H₂₂N₄O ·2HCl
• 分子量: 479.40
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (Warmed)
• 保管温度: 2-8°C

詳細

生物化学的／生理学的作用

MU1700 is a potent and selective TGF-β type I receptors ALK1/ACVRL1 & ALK2/ACVR1 inhibitor (IC50 = 13/6 nM, [ATP] = 10 mM) that inhibits ALK6/BMPR1B only at higher concentrations (IC50 = 41 nM) with good kinome selectivity over >360 other kinases, including ALK3/BMPR1A (IC50 = 425 nM), ALK4/ACVR1B & ALK5/TGFBR1 (inactive). MU1700 inhibits cellular phospho-SMAD1/5/8 induction by 10 ng/mL BMP-7 and phospho-SMAD2 induction by either 10 ng/mL activin A or 100 ng/mL TGF-β1 with good target selectivity by cellular NanoBRET assays (ALK1/2 IC50 = 225/27 nM).

注意

Hygroscopic

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable