SRP5255

HSP70, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 別名: HSP70-1, HSP72, HSPA1, HSPA1A
• CAS番号: 2071612-66-1
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥70% (SDS-PAGE)
• 形状: buffered aqueous glycerol solution
• 分子量: ~96 kDa
• NCBIアクセッション番号: NM_005345
• アプリケーション: cell analysis
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... HSPA1A(3303)

詳細

詳細

HSP70 is a member of the heat shock protein family and is synthesized by cells of many organisms in response to stress. HSP70 is found mostly but not exclusively in the nucleus of unstressed cells. For several hours after a short heat shock, however, it is strongly concentrated in nucleoli. Nucleoli are transiently damaged by such a heat shock: their morphology changes and assembly and export of ribosomes is blocked for several hours. HSP70 helps to stabilize the morphological changes of the nucleoli.
HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) is also termed as HSP72. It belongs to the molecular chaperones family. This gene is located on human chromosome 6p21.

生物化学的／生理学的作用

HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) participates in several cellular processes, such as thermotolerance, clearance of protein aggregate, survival and proliferation. Mutation in Hsp70 gene locus is linked with systemic lupus erythematosus. Overexpression of this protein is observed in valproic acid (VPA)-resistant cell lines.

物理的形状

50 mM Tris-HCl溶液（pH 7.5、150 mM NaCl、10 mM グルタチオン、0.1 mM EDTA、0.25 mM DTT、0.1 mM PMSF、25％ グリセロール）

調製ノート

開封後は少量ずつに分注して－70℃で保管してください。操作を反復したり凍結融解を何度も繰り返したりしないでください。

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable