T2067

チロホスチンAG 879

99% (HPLC)

• 別名: α-シアノ-(3,5-ジ-t-ブチル-4-ヒドロキシ)チオシンアミド
• 実験式（ヒル表記法）: C₁₈H₂₄N₂OS
• CAS番号: 148741-30-4
• 分子量: 316.46
• MDL番号: MFCD00236450
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278728
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: 99% (HPLC)
• 溶解性: DMSO: soluble (at 26 mg/ml); H₂O: insoluble
• SMILES記法: CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C
• InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
• InChI Key: XRZYELWZLNAXGE-KPKJPENVSA-N
• 遺伝子情報: human ... ERBB2(2064) , NTRK1(4914)

詳細

アプリケーション

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation¹. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation².

生物化学的／生理学的作用

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells³. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice⁴.

神経成長因子受容体(TrkA; pp140trk)およびヘレグリン受容体erbB-2(HER-2)のチロシンキナ-ゼ活性を阻害します。

特徴および利点

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調製ノート

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)