T5826

抗TSG101(N末端)抗体 ウサギ宿主抗体

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗腫瘍感受性遺伝子101抗体
• MDL番号: MFCD08705530
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ARR; WB
• クローン: polyclonal
• 化学種の反応性: mouse, human, rat
• citations: 4
• テクニック: microarray: suitable; western blot: 1-2 μg/mL using cell lysates of rat fibroblast Rat-1, mouse fibroblast NIH3T3, and human A431 cells, and rat brain extract (S1 cytosolic fraction)

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 46 kDa
• 化学種の反応性: mouse, human, rat
• 濃度: ~1 mg/mL
• テクニック: microarray: suitable; western blot: 1-2 μg/mL using cell lysates of rat fibroblast Rat-1, mouse fibroblast NIH3T3, and human A431 cells, and rat brain extract (S1 cytosolic fraction)
• UniProtアクセッション番号: Q99816
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TSG101(7251) ; mouse ... Tsg101(22088) ; rat ... Tsg101(292925)

詳細

詳細

Tumor susceptibility gene 101 protein (TSG101) is mapped to human chromosome 11p15.1. TSG101 has ubiquitin E2 variant domain.

免疫原

ヒトTSG101のN末端に位置するアミノ酸2~20に相当する合成ペプチドのＫＬＨ結合体。この配列は、ラット・マウスのTSG101と一致しています。

生物化学的／生理学的作用

Tumor susceptibility gene 101 protein (TSG101) is a component of endosomal sorting complex required for transport (ESCRT) machinery. TSG101 interacts with arrestin domain-containing protein 1 and mediates its budding through plasma membrane. It binds to ubiquitinylated proteins and conveys them for degradation by lysosomes. TSG101 is also essential for the budding human immunodeficiency virus (HIV) infected cells. TSG101 deficiency is associated with genome instability and is considered as a risk factor for tumor initiation.

物理的形状

0.01M PBS溶液(pH 7.4, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)