おすすめの製品
product name
Discovery®Cyano HPLCカラム, 5 μm particle size, L × I.D. 25 cm × 4 mm
物質
stainless steel column
品質水準
認証
suitable for USP L10
製品種目
Discovery®
特徴
endcapped
メーカー／製品名
Discovery®
包装
1 ea of
標識化の程度
4.5% Carbon loading
パラメーター
≤70 °C temp. range
400 bar pressure (5801 psi)
テクニック
HPLC: suitable
LC/MS: suitable
L × 内径
25 cm × 4 mm
表面積
200 m2/g
表面被覆率
3.5 μmol/m2
不純物
<10 ppm metals
マトリックス
silica gel, high purity, spherical base material
fully porous particle
マトリックス活性基
cyano phase
粒径
5 μm
ポアサイズ
180 Å
operating pH range
2-8
アプリケーション
food and beverages
分離法
hydrophilic interaction (HILIC)
normal phase
reversed phase
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特徴および利点
- 疎水性分析対象物の迅速な溶出に要する疎水性の低さ
- 優れたピ-ク形状および強塩基性分析対象物の保持
- 極性分析対象物の保持
- 独自の選択性
- C18カラムよりも顕著に低い保持(低濃度の有機系移動相が必要)
- 安定で低ブリ-ドのLC-MS分離
- 水系有機溶媒の濃度が高い移動相で使用可能
法的情報
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
Ye Ding et al.
Chemical communications (Cambridge, England), 47(33), 9495-9497 (2011-07-19)
A novel and facile DDQ-mediated dehydrogenation from natural rigid polycyclic acids or flexible alkyl acids to generate lactones is described. The formation of lactones proceeds by a radical ion mechanism, which has been established by DPPH˙-mediated chemical identification, ESR spectroscopy
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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