103276

Harmane

98%

• 동의어(들): 1-Methyl-9H-pyrido[3,4-b]indole, 2-Methyl-β-carboline, Aribine
• 실험식(Hill 표기법): C₁₂H₁₀N₂
• CAS Number: 486-84-0
• Molecular Weight: 182.22
• Beilstein: 143898
• EC Number: 207-642-2
• MDL number: MFCD00004957
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24846602
• NACRES: NA.22

속성

• 분석: 98%
• drug control: stupéfiant (France)
• mp: 235-238 °C (lit.)
• solubility: methanol: soluble 50mg/ml
• SMILES string: Cc1nccc2c3ccccc3[nH]c12
• InChI: 1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
• InChI key: PSFDQSOCUJVVGF-UHFFFAOYSA-N
• 유전자 정보: human ... CYP2D6(1565) ; rat ... Gabra2(29706)

설명

일반 설명

• Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
• It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
• Blood harmane concentration is elevated in essential tremor, late-life neurological disease.

애플리케이션

• Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
• It was used to study interactions of norharman and harman with DNA.
• It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

생화학적/생리학적 작용

I₁ imidazoline binding site agonist.

제조 메모

Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315
• 예방조치 성명서: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Oral - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)