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Merck
모든 사진(2)

주요 문서

159034

Sigma-Aldrich

Acetohydroxamic acid

98%

동의어(들):

AHA

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About This Item

Linear Formula:
CH3CONHOH
CAS Number:
Molecular Weight:
75.07
Beilstein:
1739019
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

분석

98%

mp

88-90 °C (lit.)

작용기

amine

SMILES string

CC(NO)=O

InChI

1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)

InChI key

RRUDCFGSUDOHDG-UHFFFAOYSA-N

유전자 정보

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일반 설명

Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.

애플리케이션

Acetohydroxamic acid was used:
  • to study the mechanism of complexation of iron (III) with acetohydroxamic acid
  • to study the inhibitory mechanism of lansoprazole and omeprazole on Helicobacter pyloni
  • in urease inhibition studies
  • for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile
Used in urease inhibition studies and for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.

픽토그램

Health hazard

신호어

Danger

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

개인 보호 장비

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges


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시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

D P Griffith et al.
The Journal of urology, 140(2), 318-324 (1988-08-01)
Acetohydroxamic acid is known to inhibit bacterial urease activity, thus, reducing urinary ammonia levels. A double-blind placebo-controlled clinical trial of acetohydroxamic acid was conducted at 12 Veterans Administration spinal cord injury units. A total of 210 male spinal cord injury
Zbl. Bakt., 275, 63-63 (1991)
Journal of the Chemical Society. Perkin Transactions 1, 1001-1001 (1991)
K Nagata et al.
Antimicrobial agents and chemotherapy, 37(4), 769-774 (1993-04-01)
The gastric proton pump inhibitor lansoprazole, its active analog AG-2000, and omeprazole dose dependently inhibited urease activity extracted with distilled water from Helicobacter pylori cells; the 50% inhibitory concentrations were between 3.6 and 9.5 microM, which were more potent than
Chem. Abstr., 116, 124530f-124530f (1992)

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