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Merck
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주요 문서

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490024

Sigma-Aldrich

L-Glutamine-(amide-15N)

98 atom % 15N

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About This Item

Linear Formula:
H215NCO(CH2)2CH(NH2)CO2H
CAS Number:
59681-32-2
Molecular Weight:
147.14
MDL number:
MFCD00084214
UNSPSC 코드:
12352209
PubChem Substance ID:
24872517
NACRES:
NA.12

동위원소 순도

98 atom % 15N

Quality Level

200

분석

99% (CP)

형태

solid

광학 활성

[α]25/D +33.0°, c = 2 in 5 M HCl

mp

185 °C (dec.) (lit.)

질량 이동

M+1

SMILES string

N[C@@H](CCC([15NH2])=O)C(O)=O

InChI

1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1/i7+1

InChI key

ZDXPYRJPNDTMRX-QQKKVIQDSA-N

일반 설명

L-Glutamine is a branched chain, non-essential amino acid. It is one of the most abundant amino acid found in central nervous system (CNS), plasma and human skeletal muscle.(2) L- Glutamine is synthesized by transamination of glutamate catalyzed by glutamine synthetase.

생화학적/생리학적 작용

L-Glutamine, a source of nitrogen, mainly contributes to the synthesis of proteins, peptides, purine, pyrimidine, nucleotides, nucleic acids and major precursor of neurotransmitter. It acts as a fuel for the proliferation of lymphocytes and macrophages of immune system, for intestinal tissue to maintain gut integrity and for insulin production.(4)(3) L-Glutamine is released by skeletal muscle during stress conditions.

포장

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
MBBD6227
MBBD1218
MBBC8990
MBBC7485
MBBC4064

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문서 라이브러리 방문

Glutamine and glutamate as vital metabolites
Newsholme P, et al.
Brazilian journal of medical and biological research, 36(2), 153-163 (2003)
The influence of oral L-glutamine supplementation on muscle strength recovery and soreness following unilateral knee extension eccentric exercise
Legault Z, et al.
International Journal of Sport Nutrition and Exercise Metabolism, 25(5), 417-426 null
Katarzyna Dąbrowska et al.
Neurochemistry international, 118, 225-232 (2018-07-19)
SN1, a system N amino acid transporter specific for astrocytes, is mainly responsible for export of newly synthesized L-glutamine from the cells. Astrocytic retention of L-glutamine which plays a critical role in ammonia-induced astrocytic swelling resulting in brain edema, could
Liangxian Cao et al.
Molecular cancer therapeutics, 18(1), 3-16 (2018-10-26)
PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we performed extensive biological characterization of the activity of PTC299 and
Min Yuan et al.
Nature protocols, 14(2), 313-330 (2019-01-27)
Targeted tandem mass spectrometry (LC-MS/MS) has been extremely useful for profiling small molecules extracted from biological sources, such as cells, bodily fluids and tissues. Here, we present a protocol for analysing incorporation of the non-radioactive stable isotopes carbon-13 (13C) and
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