902543

Propargyl-PEG4-acid

• 동의어(들): 4,7,10,13-Tetraoxahexadec-15-ynoic acid, Propargyl-PEG4-CH₂CO₂H
• 실험식(Hill 표기법): C₁₂H₂₀O₆
• CAS Number: 1415800-32-6
• Molecular Weight: 260.28
• MDL number: MFCD22683284
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• 형태: liquid
• 반응 적합성: reagent type: linker
• 재고 정보: available only in USA
• refractive index: n/D 1.460
• density: 1.164 g/mL
• 작용기: alkyne; carboxylic acid
• 저장 온도: −20°C
• SMILES string: OC(CCOCCOCCOCCOCC#C)=O

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

기타 정보

Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• 픽토그램: GHS02
• 신호어: Danger
• 유해 및 위험 성명서: H242
• 예방조치 성명서: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class Code: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable