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Merck
모든 사진(2)

주요 문서

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909300

Sigma-Aldrich

Carboxylic acid-poly(ethylene glycol)-b-poly(D,L lactide)

PEG average Mn 5,000, PDLA average Mn 16,000

동의어(들):

COOH-PEG-PDLA, COOH-PEG-PLA, Carboxylic acid PEG-PDLA, Carboxylic acid-PEG-PLA

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모든 사진(2)

About This Item

Linear Formula:
HO(C3H4O2)m(C2H4O)nC2H3O2
UNSPSC 코드:
12352106
NACRES:
NA.23

형태

powder or chunks

분자량

PDLA average Mn 16,000 (by NMR)
PEG average Mn 5,000 (by NMR)

색상

white to tan

저장 온도

−20°C

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관련 카테고리

애플리케이션

Carboxylic acid-poly(ethylene glycol)-b-poly(D,L lactide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Ren Zhong Xiao et al.
International journal of nanomedicine, 5, 1057-1065 (2010-12-21)
Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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