909432

Fluorinated VHL Spy Molecule 2

≥98%

• 동의어(들): (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide, VHL reporter ligand
• 실험식(Hill 표기법): C₁₄H₁₄BrF₃N₂O₃
• CAS Number: 2290526-27-9
• Molecular Weight: 395.17
• UNSPSC 코드: 12352101

속성

• ligand: VH032 derivative
• 분석: ≥98%
• 형태: powder
• SMILES string: O=C([C@@H]1C[C@@H](O)CN1C(C(F)(F)F)=O)NCC2=CC=C(Br)C=C2

설명

애플리케이션

Fluorinated VHL Spy Molecule 2 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909459, 909440, and 909416.
The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable