911690

C5 Lenalidomide

≥95%

• 동의어(들): 3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 ligase ligand, Ligand for PROTAC^® research
• 실험식(Hill 표기법): C₁₃H₁₃N₃O₃
• CAS Number: 191732-70-4
• Molecular Weight: 259.26
• MDL number: MFCD31692701
• UNSPSC 코드: 12352101
• NACRES: NA.22

속성

• ligand: C5 Lenalidomide
• Quality Level: 100
• 분석: ≥95%
• 양식: powder
• 반응 적합성: reagent type: ligand
• 저장 온도: 2-8°C
• SMILES string: NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1
• InChI: 1S/C13H13N3O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6,14H2,(H,15,17,18)
• InChI key: WLUIQUZGNPAKRL-UHFFFAOYSA-N

설명

애플리케이션

C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

기타 정보

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Targeted Protein Degradation by Small Molecules

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361d,H373
• 예방조치 성명서: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2 - STOT RE 2
• 표적 기관: Blood
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable