T144

(±)-Thalidomide

≥98%, powder

• 동의어(들): (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• 실험식(Hill 표기법): C₁₃H₁₀N₂O₄
• CAS Number: 50-35-1
• Molecular Weight: 258.23
• EC Number: 200-031-1
• MDL number: MFCD00153873
• UNSPSC 코드: 12352111
• eCl@ss: 39180303
• PubChem Substance ID: 24278765
• NACRES: NA.77

속성

• ligand: thalidomide
• 분석: ≥98%
• 형태: powder
• 반응 적합성: reagent type: ligand
• 색상: white
• solubility: DMSO: 20 mg/mL, clear
• 주관자: Celgene
• SMILES string: O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
• InChI: 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
• InChI key: UEJJHQNACJXSKW-UHFFFAOYSA-N
• 유전자 정보: human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , LITAF(9516) , RBX1(9978) , TNF(7124) ; mouse ... Nos2(18126) ; rat ... Nos1(24598)

설명

애플리케이션

Thalidomide has been used to study its neuropathological effects in mouse models of Alzheimer′s disease (AD). This study reported that long term administration of thalidomide causes beta-secretase inhibition and subsequently alleviates amyloid-like pathology. Furthermore, thalidomide has also been used to evaluate its teratogenic functions. Thalidomide was found to affect endodermal differentiation and neural development in differentiating human embryonic and induced pluripotent stem cells.

생화학적/생리학적 작용

(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). It also functions as an inhibitor of angiogenesis, an immunosuppressive agent, a sedative and a teratogen. Furthermore, thalidomide is known to exhibit antitumor functions in refractory multiple myeloma.

특징 및 장점

This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

Thalidomide is soluble in DMSO at a concentration that is more than 20 mg/ml. It is insoluble in water and ethanol.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H312,H360D
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges