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Merck
모든 사진(2)

주요 문서

901487

Sigma-Aldrich

(S,S,S)-AHPC hydrochloride

≥97%

동의어(들):

(2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand negative control epimer, Ligand for PROTAC® research, VH032 negative control

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About This Item

실험식(Hill 표기법):
C22H30N4O3S · xHCl
CAS Number:
Molecular Weight:
430.56 (free base basis)
MDL number:
UNSPSC 코드:
12352101
NACRES:
NA.22

ligand

VH032

Quality Level

분석

≥97%

양식

powder or crystals

반응 적합성

reagent type: ligand

저장 온도

2-8°C

SMILES string

N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@H](O)C1)=O)C(C)(C)C.Cl

InChI

1S/C22H30N4O3S.ClH/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4;/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28);1H/t16-,17-,19+;/m0./s1

InChI key

JYRTWGCWUBURGU-ITJMAPPJSA-N

관련 제품

제품 번호
설명
가격

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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Journal of medicinal chemistry, 61(2), 583-598 (2017-07-12)
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Angewandte Chemie (International ed. in English), 55(6), 1966-1973 (2016-01-13)
The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inhibition, 2) high in vivo concentrations bring potential for off-target side effects, and 3) there is

문서

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