추천 제품
형태
viscous liquid
Quality Level
불순물
<5 CFU/g Bioburden (Total Aerobic)
<5 CFU/g Bioburden (fungal)
<50 EU/mL Endotoxin
색상
white
pH
6.5-7.5
점도
5-50 cP(37 °C)
응용 분야
3D bioprinting
일반 설명
TissueFab® bioink Bone Vis/405 nm, is designed for promoting osteogenic differentiation of stem cells. It is based on Gelatin methacryloyl (GelMA) - Hydroxyapatite (HAp) hydrogel system.
HAp is a highly crystalline form of calcium phosphate. HAp has a chemical similarity with the mineralized phase of bone which accounts for their excellent biocompatibility and osteoinductive and osteoconductive properties favorable for bone regeneration. HAp-containing hydrogels has been studied in literature to demonstrate their processability with different additive manufacturing approaches. Printing of cell laden structures with HAp containing bioink formulations have shown superior osteogenic properties.
Additional Information:
The protocol for this material can be found In the Documentation Section under ″More Documents″.
HAp is a highly crystalline form of calcium phosphate. HAp has a chemical similarity with the mineralized phase of bone which accounts for their excellent biocompatibility and osteoinductive and osteoconductive properties favorable for bone regeneration. HAp-containing hydrogels has been studied in literature to demonstrate their processability with different additive manufacturing approaches. Printing of cell laden structures with HAp containing bioink formulations have shown superior osteogenic properties.
Additional Information:
The protocol for this material can be found In the Documentation Section under ″More Documents″.
애플리케이션
TissueFab® bioink Bone UV/365 nm, low endotoxin is a ready-to-use bioink which is formulated for high cell viability, osteoinduction and printing fidelity and is designed for extrusion-based 3D bioprinting and subsequent crosslinking with exposure to 405 nm visible light. GelMA-Bone bioinks can be used with most extrusion-based bioprinters, are biodegradable, and are compatible with human mesenchymal stem cells (hMSCs) and osteogenic cell types. TissueFab® bioink Bone UV/365 nm, low endotoxin enables the precise fabrication of osteogenic 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine.
법적 정보
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Nano hydroxyapatite particles promote osteogenesis in a three-dimensional bio-printing construct consisting of alginate/gelatin/hASCs.
Wang X F, et al.
Royal Society of Chemistry Advances, 6, 6832?42-6832?42 (2016)
Silke Wüst et al.
Acta biomaterialia, 10(2), 630-640 (2013-10-26)
Three-dimensional (3-D) bioprinting is the layer-by-layer deposition of biological material with the aim of achieving stable 3-D constructs for application in tissue engineering. It is a powerful tool for the spatially directed placement of multiple materials and/or cells within the
Michal Bartnikowski et al.
Materials (Basel, Switzerland), 9(4) (2016-04-14)
The concept of biphasic or multi-layered compound scaffolds has been explored within numerous studies in the context of cartilage and osteochondral regeneration. To date, no system has been identified that stands out in terms of superior chondrogenesis, osteogenesis or the
Mehdi Sadat-Shojai et al.
Materials science & engineering. C, Materials for biological applications, 49, 835-843 (2015-02-18)
The ability to encapsulate cells in three-dimensional (3D) protein-based hydrogels is potentially of benefit for tissue engineering and regenerative medicine. However, as a result of their poor mechanical strength, protein-based hydrogels have traditionally been considered for soft tissue engineering only.
Yicong Zuo et al.
ACS applied materials & interfaces, 7(19), 10386-10394 (2015-05-01)
Modular tissue engineering holds great potential in regenerating natural complex tissues by engineering three-dimensional modular scaffolds with predefined geometry and biological characters. In modular tissue-like construction, a scaffold with an appropriate mechanical rigidity for assembling fabrication and high biocompatibility for
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