930075

2-fluoro-6-(pyrimidin-5-yl)aniline

≥95%

• 실험식(Hill 표기법): C₁₀H₈FN₃
• CAS Number: 1697040-97-3
• Molecular Weight: 189.19
• UNSPSC 코드: 12352106
• NACRES: NA.06

속성

• Quality Level: 100
• 분석: ≥95%
• 양식: powder, crystals or chunks
• 색상: light yellow
• 작용기: fluoro
• 저장 온도: −20°C
• SMILES string: NC1=C(C2=CN=CN=C2)C=CC=C1F
• InChI: 1S/C10H8FN3/c11-9-3-1-2-8(10(9)12)7-4-13-6-14-5-7/h1-6H,12H2
• InChI key: RLVGAYVNMWBWFQ-UHFFFAOYSA-N

설명

애플리케이션

2-fluoro-6-(pyrimidin-5-yl)aniline is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.


2-fluoro-6-(pyrimidin-5-yl)aniline is an effective TDG for meta directed C-H functionalization of aldehyde substituted target compounds, with high selectivity.

기타 정보

1. Imine as a linchpin approach for meta-C–H functionalization2. Transient directing ligands for selective metal-catalysed C–H activation

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable