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Merck
모든 사진(1)

주요 문서

QBD10247

Sigma-Aldrich

Thiol-dPEG®4-acid

>95% (HPLC)

동의어(들):

Carboxy-PEG4-thiol, HS-PEG4-COOH, Thiol-PEG-acid, Thiol-PEG4-COOH, Thiol-PEG4-acid

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About This Item

실험식(Hill 표기법):
C11H22O6S
Molecular Weight:
282.35
MDL number:
UNSPSC 코드:
12352106
NACRES:
NA.22

분석

>95% (HPLC)

양식

solid or viscous liquid

반응 적합성

reaction type: Pegylations

폴리머 구조

shape: linear
functionality: heterobifunctional

배송 상태

ambient

저장 온도

−20°C

SMILES string

SCCOCCOCCOCCOCCC(=O)O

InChI

1S/C11H22O6S/c12-11(13)1-2-14-3-4-15-5-6-16-7-8-17-9-10-18/h18H,1-10H2,(H,12,13)

특징 및 장점

Thiol-dPEG4-acid is a sulfhydryl-containing, crosslinking PEGylation reagent that has a cross-bridge of monodisperse polyethylene glycol. The single molecular weight, discrete-length PEG (dPEG) chain is 16 atoms (18.3 Å) long. The sulfhydryl end of the crosslinker reacts with gold (forming dative bonds) and with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.

법적 정보

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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