추천 제품
설명
cholest-5-ene-3β,24(S)-diol
분석
>99% (TLC)
형태
powder
포장
pkg of 1 × 1 mg (700061P-1mg)
pkg of 1 × 5 mg (700061P-5mg)
제조업체/상표
Avanti Research™ - A Croda Brand
배송 상태
dry ice
저장 온도
−20°C
InChI
1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
InChI key
IOWMKBFJCNLRTC-XWXSNNQWSA-N
일반 설명
24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1). It is catabolized to bile acids in the liver.
애플리케이션
24(S)-hydroxycholesterol has been used as an internal standard:
- in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
- in liquid chromatography with tandem mass spectrometry (LC-MS/MS) for the quantification of 27-hydroxycholesterol from colorectal tumor samples
- for quantification of human plasma sterols by liquid chromatography with tandem mass spectrometry (LC MS/MS)
생화학적/생리학적 작용
24(S)-hydroxycholesterol (24HC) elevated levels are reported in liver inflammation and fibrosis. It is a N-methyl-D-aspartate receptor (NMDAR) modulator. The levels of 24HC are potential indicators of brain development as well as pathology including Alzheimer′s disease (AD) and multiple sclerosis. Polymorphism in the cholesterol 24-hydroxylase (CYP46A1) gene leads to elevated 24HC levels and toxicity. 24HC is a mediator of apoptosis and necroptosis. Elevated levels of 24HC are reported in liver inflammation and fibrosis.
포장
5 mL Amber Glass Screw Cap Vial (700061P-1mg)
5 mL Amber Glass Screw Cap Vial (700061P-5mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Diverse functions of 24 (S)-hydroxycholesterol in the brain
Noguchi N, et al.
Biochemical and Biophysical Research Communications, 446(3), 692-696 (2014)
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
Sun MY, et al.
Testing, 12(3) (2017)
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
Sun MY, et al.
PLoS ONE, 12(3) (2017)
The acidic pathway of bile acid synthesis: Not just an alternative pathway
Pandak WM and Kakiyama G
Liver research (2019)
A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4beta-hydroxycholesterol in human plasma
van de Merbel NC, et al.
Journal of Pharmaceutical and Biomedical Analysis, 55(5), 1089-1095 (2011)
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