860537P

Galactosyl(β) Sphingosine (d18:1)

Avanti Research^™ - A Croda Brand 860537P, powder

• 동의어(들): D-galactosyl-β1-1′-D-erythro-sphingosine
• 실험식(Hill 표기법): C₂₄H₄₇NO₇
• CAS Number: 2238-90-6
• Molecular Weight: 461.63
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 형태: powder
• 포장: pkg of 1 × 25 mg (860537P-25mg); pkg of 1 × 5 mg (860537P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 860537P
• 지질 유형: sphingolipids
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
• InChI: 1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21-,22-,23+,24+/m0/s1
• InChI key: HHJTWTPUPVQKNA-PIIMIWFASA-N

설명

일반 설명

Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.

애플리케이션

Galactosyl(β) Sphingosine (d18:1) has been used in the liposome preparation for α-synuclein aggregation studies. It is suitable for use to test its inhibitory effect on cytokinesis in cells expressing T-cell death-associated gene 8 (TDAG8). It is also suitable for use as a standard for differential mobility spectrometry (DMS) coupled with liquid chromatography in electrospray ionizatoin tandem mass spectrometry (LC-ESI-DMS-MS/MS) for ceramide quantification and ultra-high resolution ion mobility spectrometry measurments.

생화학적/생리학적 작용

Galatosylsphingosine or psychosine is a cytotoxic lipid which accumulates in oligodendrocytes due to dysfunctional lysosomal enzyme galactosylceramidase and is implicated in globoid cell leukodystrophy. Psychosine accumulation induces demyelination, astrocyte dysfunction and pro-inflammatory cytokine release in Krabbe disease.

포장

5 mL Amber Glass Screw Cap Vial (860537P-25mg)

5 mL Amber Glass Screw Cap Vial (860537P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable