추천 제품
분석
>99% (TLC)
양식
powder
포장
pkg of 1x10 mg (900407P-10MG)
pkg of 1 × 1 mg (900407P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 900407P
지질 유형
click reagents
phospholipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
C#CCCCC1(N=N1)CCCCCCCCC(O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCCCCCC)=O)=O
InChI
1S/C39H72N3O8P/c1-6-8-10-11-12-13-14-15-16-17-18-21-24-28-37(43)47-34-36(35-49-51(45,46)48-33-32-42(3,4)5)50-38(44)29-25-22-19-20-23-27-31-39(40-41-39)30-26-9-7-2/h2,36H,6,8-35H2,1,3-5H3/t36-/m1/s1
InChI key
XBLDRLHMTZEHJM-PSXMRANNSA-N
일반 설명
The pacFA lipid attached to 1-palmitoyl-sn-glycero-3-phosphocholine, contains a photoactivable diazirine ring with a clickable alkyne group.
애플리케이션
1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine (16:0-pacFA PC) might be used to label hydrogenated zwitterionic bicelles (HZB) and hydrogenated anionic bicelles (HAB).
생화학적/생리학적 작용
1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine (16:0-pacFA PC) may be used for a global analysis of protein–lipid interactions in living cells. pacFA acts as a precursor for the biosynthesis of bifunctional lipids. Proteins in contact with the bifunctional lipids are then cross-linked by ultraviolet (UV) irradiation of the diazirine ring. Finally, click chemistry is used to label the alkyne with a reporter molecule.
포장
5 mL Amber Glass Screw Cap Vial (900407P-10MG)
5 mL Amber Glass Screw Cap Vial (900407P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Flash Point (°F)
No data available
Flash Point (°C)
No data available
가장 최신 버전 중 하나를 선택하세요:
Raphael Dos Santos Morais et al.
Biophysical journal, 115(7), 1231-1239 (2018-09-11)
Scaffolding proteins play important roles in supporting the plasma membrane (sarcolemma) of muscle cells. Among them, dystrophin strengthens the sarcolemma through protein-lipid interactions, and its absence due to gene mutations leads to the severe Duchenne muscular dystrophy. Most of the
Dominique Mias-Lucquin et al.
Journal of structural biology, 209(1), 107411-107411 (2019-11-07)
Dystrophin is a large intracellular protein that prevents sarcolemmal ruptures by providing a mechanical link between the intracellular actin cytoskeleton and the transmembrane dystroglycan complex. Dystrophin deficiency leads to the severe muscle wasting disease Duchenne Muscular Dystrophy and the milder
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.
Per Haberkant et al.
Angewandte Chemie (International ed. in English), 52(14), 4033-4038 (2013-03-02)
Per Haberkant et al.
Biochimica et biophysica acta, 1841(8), 1022-1030 (2014-01-21)
Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as
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