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LM1904

Avanti

17:0-20:4 PI(4,5)P2

Avanti Research™ - A Croda Brand LM1904, powder

동의어(들):

1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)

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About This Item

실험식(Hill 표기법):
C46H92N3O19P3
CAS Number:
1246304-70-0
Molecular Weight:
1084.15
UNSPSC 코드:
12352211
NACRES:
NA.25

양식

powder

제조업체/상표

Avanti Research™ - A Croda Brand LM1904

포장

1 ea of 1 × (with stopper and crimp cap (LM1904-1EA))

응용 분야

lipidomics
metabolomics

배송 상태

dry ice

저장 온도

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

InChI

1S/C46H83O19P3.3H3N/c1-3-5-7-9-11-13-15-17-19-20-21-23-25-27-29-31-33-35-40(48)62-38(36-60-39(47)34-32-30-28-26-24-22-18-16-14-12-10-8-6-4-2)37-61-68(58,59)65-44-41(49)42(50)45(63-66(52,53)54)46(43(44)51)64-67(55,56)57;;;/h11,13,17,19,21,23,27,29,38,41-46

InChI key

OKMXNUJCHZSHOL-TZFFBZLFSA-N

애플리케이션

17:0-20:4 PI(4,5)P2 or 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) has been used:
  • as an internal standard in liquid chromatography tandem mass spectroscopy (LC-MS/MS) experiments
  • as a lipid standard in ultra-performance liquid chromatography-tandem mass spectrometry (UPLC/MS)
  • as a standard to measure phosphatidylinositol (4,5)P2 from fibroblasts and brain samples by MS

생화학적/생리학적 작용

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is critical for the phosphoinositide signaling. It acts as a primary messenger and can also as a precursor for many secondary messengers involved. PI(4,5)P2 serves as a substrate for phosphoinositide 3-kinase (PI3K) to form phosphatidylinositol 3,4,5-trisphosphate (PI3,4,5P3).

포장

2 mL Amber Serum Vial with Stopper and Crimp Cap (LM1904-1EA)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Prasenjit Manna et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(4), 1253-1275 (2015-02-28)
Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P₃) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains. Localization and activation of these effector proteins regulate a number of cellular functions
Anthony M Battram et al.
The Journal of biological chemistry, 292(5), 1691-1704 (2016-12-03)
The class I PI3K family of lipid kinases plays an important role in integrin αIIbβ3 function, thereby supporting thrombus growth and consolidation. Here, we identify Ras/Rap1GAP Rasa3 (GAP1IP4BP) as a major phosphatidylinositol 3,4,5-trisphosphate-binding protein in human platelets and a key
Avishek Ghosh et al.
Bioscience reports, 39(10) (2019-10-28)
Phosphatidylinositol-5-phosphate (PI5P) is a low abundance lipid proposed to have functions in cell migration, DNA damage responses, receptor trafficking and insulin signalling in metazoans. However, studies of PI5P function are limited by the lack of scalable techniques to quantify its
Maria Saliakoura et al.
Oncogene, 39(14), 2948-2960 (2020-02-09)
Enhanced prostaglandin production promotes the development and progression of cancer. Prostaglandins are generated from arachidonic acid (AA) by the action of cyclooxygenase (COX) isoenzymes. However, how cancer cells are able to maintain an elevated supply of AA for prostaglandin production
Oscar Vivas et al.
Cell reports, 27(9), 2636-2648 (2019-05-30)
There is increasing evidence that the lysosome is involved in the pathogenesis of a variety of neurodegenerative disorders. Thus, mechanisms that link lysosome dysfunction to the disruption of neuronal homeostasis offer opportunities to understand the molecular underpinnings of neurodegeneration and
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