추천 제품
Grade
certified reference material
Quality Level
형태
liquid
특징
SNAP-N-SPIKE®, SNAP-N-SHOOT®
포장
ampule of 1 mL
제조업체/상표
Cerilliant®
농도
1.0 mg/mL in methanol
기술
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
응용 분야
clinical testing
형식
single component solution
저장 온도
−20°C
SMILES string
CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
InChI
1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key
QZUDBNBUXVUHMW-UHFFFAOYSA-N
유전자 정보
human ... DRD2(1813) , HTR2A(3356)
일반 설명
A Certified Snap-N-Spike® Solution for use in clinical toxicology, forensic analysis, or urine drug testing applications by LC/MS or GC/MS. Clozapine, sold as Clozaril® and FazaClo® in the US, is an atypical antipsychotic drug used for treatment of schizophrenia.
애플리케이션
- Augmentation Strategies for Clozapine Non-responders: A Bayesian network meta-analysis evaluated augmentation strategies for patients with schizophrenia who show partial or no response to clozapine, providing insights into effective secondary treatment options (Mishra et al., 2024).
- Antipsychotic Pre-treatment and Clozapine Metabolism: Research highlighted the impact of rapid metabolism of antipsychotics prior to clozapine treatment, affecting serum levels and suggesting a need for adjusted dosing strategies in treatment-resistant schizophrenia (Lenk HÇ et al., 2024).
- Genetic Influences on Clozapine Side Effects: A study identified polymorphisms in ERBB4 and TACR1 genes associated with dry mouth in patients treated with clozapine, pointing towards personalized management strategies for side effects (Puolakka et al., 2024).
- Therapeutic Mechanisms of Antipsychotics: An analysis focused on understanding the therapeutic mechanisms of antipsychotics including clozapine, examining cellular and molecular targets and their implications for optimizing treatment efficacy in psychiatric disorders (Direktor et al., 2024).
- Clozapine and Metabolic Syndrome in Schizophrenia: A study assessed the association between cytokine levels, psychopathology, and cognitive functions in clozapine-treated schizophrenia patients with metabolic syndrome, providing data critical for holistic treatment approaches (Dong et al., 2024).
법적 정보
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Clozaril is a registered trademark of Sandoz, Inc.
FazaClo is a registered trademark of Jazz Pharmaceuticals International III Limited
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
표적 기관
Eyes,Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point (°F)
49.5 °F - closed cup
Flash Point (°C)
9.7 °C - closed cup
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Chun-Hsin Chen et al.
The Journal of clinical psychiatry, 74(5), e424-e430 (2013-06-14)
Many studies have shown that metformin can decrease body weight and improve metabolic abnormalities in patients with schizophrenia. Whether or not the beneficial effects can be sustained after discontinuation of metformin needs to be evaluated. We conducted a 24-week randomized
Galvin Vredenburg et al.
Toxicology letters, 222(3), 247-256 (2013-08-07)
Clozapine, an often-prescribed antipsychotic drug, is implicated in severe adverse drug reactions (ADRs). Formation of reactive intermediates by cytochrome P450s (CYPs) has been proposed as a possible explanation for these ADRs. Moreover, a protective role for human glutathione S-transferases (hGSTs)
Shalini Jain et al.
The Journal of clinical investigation, 123(4), 1750-1762 (2013-03-13)
Type 2 diabetes (T2D) has emerged as a major threat to human health in most parts of the world. Therapeutic strategies aimed at improving pancreatic β cell function are predicted to prove beneficial for the treatment of T2D. In the
Chao-Cheng Lin et al.
Journal of clinical psychopharmacology, 33(2), 211-214 (2013-02-21)
Clozapine is the most effective antipsychotic for patients with treatment-refractory schizophrenia, but many adverse effects are noted. Clinicians usually hesitate to switch from clozapine to other antipsychotics because of the risk of a re-emergence or worsening of the psychosis, although
Bianca A Silva et al.
Nature neuroscience, 16(12), 1731-1733 (2013-11-12)
The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and
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