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Merck
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O-004

Supelco

Oxymorphone solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

실험식(Hill 표기법):
C17H19NO4
CAS Number:
76-41-5
Molecular Weight:
301.34
MDL number:
MFCD00079194
UNSPSC 코드:
41116107
PubChem Substance ID:
329818813
NACRES:
NA.24

Grade

certified reference material

Quality Level

300

양식

liquid

특징

Snap-N-Spike®/Snap-N-Shoot®

포장

ampule of 1 mL

제조업체/상표

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

농도

1.0 mg/mL in methanol

기술

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

응용 분야

forensics and toxicology

형식

single component solution

저장 온도

2-8°C

SMILES string

CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@]2(O)CCC4=O)c35

InChI

1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1

InChI key

UQCNKQCJZOAFTQ-ISWURRPUSA-N

유전자 정보

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)

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관련 카테고리

일반 설명

A certified Snap-N-Spike® solution of oxymorphone suitable for use in a variety of GC/MS or LC/MS applications from pain prescription monitoring, clinical toxicology, and pharmaceutical research to forensic analysis and urine drug testing. Oxymorphone, sold under trade names such as Opana®, Numorphan®, and Numorphone, is an opiate analgesic indicated for the relief of moderate to severe pain.

애플리케이션


  • Advanced UHPLC-MS/MS Methodology: A novel ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method has been developed for quantifying oxymorphone along with other opioids in various human tissues. This technique is crucial for understanding the pharmacokinetics and tissue distribution of synthetic opioids, providing valuable data for both clinical and pharmaceutical research (Manca et al., 2023).

  • Genetic Association Studies: Oxymorphone′s application extends to genetic studies where its interaction with the CYP2D6 genotype is analyzed to determine individual responses in opioid analgesia. This research is critical for optimizing pain management strategies and reducing adverse effects in treatments involving synthetic opioids (Merchant et al., 2022).

  • Drug Safety and Regulation: Oxymorphone is a focus of regulatory review processes, particularly in the context of the opioid crisis. Analyzing the decisions and advisories concerning oxymorphone helps in understanding its role in current medical practice and its impact on public health policies (Litman, 2020).

  • Innovative Analytical Techniques: Research includes the development of advanced analytical techniques, such as gas chromatography-mass spectrometry, for detecting oxymorphone in biological samples. These methods are essential for clinical diagnostics and forensic investigations, ensuring accurate and sensitive detection of this potent analgesic (Norouzi et al., 2020).

  • In Vitro Safety Evaluations: Oxymorphone is also studied in in vitro models to assess its hemolytic potential when abused intravenously. This research is crucial for understanding the risks associated with non-prescribed administration routes and contributes to safer pharmaceutical formulations (Persich et al., 2020).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Numorphan is a registered trademark of Endo Pharmaceuticals Inc.
Opana is a registered trademark of Endo Pharmaceuticals Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

관련 제품

제품 번호
설명
가격

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

H-098

6α/β-Hydroxyoxymorphone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-012

Noroxymorphone hydrochloride solution, 1.0 mg/mL in methanol: DMSO (80:20) (as free base), ampule of 1 mL, certified reference material, Cerilliant®

O-003

Oxymorphone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

O-019

Oxymorphone-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

O-030

Oxymorphone-3-β-D-glucuronide solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

O-031

Oxymorphone-D3-3-β-D-glucuronide solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

O-004S

Oxymorphone solution, 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

픽토그램

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H225,H301 + H311 + H331,H370

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point (°F)

49.5 °F - closed cup

Flash Point (°C)

9.7 °C - closed cup

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

M Spetea et al.
Current medicinal chemistry, 19(15), 2442-2457 (2012-03-30)
Morphine and other opioid morphinans produce analgesia primarily through μ opioid receptors (MORs), which mediate beneficial but also non-beneficial actions. There is a continued search for efficacious opioid analgesics with reduced complications. The cornerstone in the development of 14-alkoxymorphinans as
Deborah French et al.
Bioanalysis, 3(23), 2603-2612 (2011-12-06)
In clinical laboratories, a large proportion of the toxicology workload is drug confirmations. Our GC-MS method for opioid confirmation detects total codeine, morphine, hydrocodone, hydromorphone, oxycodone and oxymorphone. The objective of this study was to develop a LC-MS/MS assay measuring
Mark P Jensen et al.
The Clinical journal of pain, 29(4), 289-295 (2012-10-09)
To understand the factors that contribute to patient and physician global outcome ratings and the extent to which receiving different doses of opioids or placebo might influence the importance of these factors better. A secondary analysis was performed using data
Trine Naalsund Andreassen et al.
European journal of clinical pharmacology, 68(1), 55-64 (2011-07-08)
Opioids are recommended by the World Health Organization for moderate to severe cancer pain. Oxycodone is one of the most commonly used opioids and is metabolized in the liver by CYP3A4 and CYP2D6 enzymes. The aim of this cross-sectional study
Marco Pappagallo et al.
Postgraduate medicine, 124(5), 101-109 (2012-10-26)
Because rates of both opioid prescribing and opioid abuse have increased, drug companies have responded by considering strategies to make opioid formulations less attractive for abuse without compromising safety or efficacy for patients with legitimate pain management needs. The emergence
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