203732

Brevetoxin PbTx-2

from Ptychodiscus brevis, ≥95% (HPLC), solid, Na+ channel-binding neurotoxin, Calbiochem^®

• 동의어(들): Brevetoxin PbTx-2, Ptychodiscus brevis, Brevetoxin B, GbTx-2
• 실험식(Hill 표기법): C₅₀H₇₀O₁₄
• CAS Number: 79580-28-2
• Molecular Weight: 895.08
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• product name: Brevetoxin PbTx-2, Ptychodiscus brevis, Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes.
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: tan to white
• solubility: ethyl acetate: soluble; methanol: soluble; water: soluble
• 배송 상태: wet ice
• 저장 온도: −20°C
• InChI: 1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-
• InChI key: LYTCVQQGCSNFJU-KTKRTIGZSA-N

설명

일반 설명

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na⁺ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.

Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes. Binds at site 5 on the voltage-sensitive Na⁺ channel.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Neurotoxin that binds to Na+ channels on nerves and muscles.

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

yes

경고

Toxicity: Highly Toxic (H)

재구성

Following reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.





From Catalog:

Solubitlity- removed acetone, EtOAc

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Edwards, R.A., et al. 1992. Mol. Brain Res.14, 64.
Trainer, V.L. 1991. Mol. Pharmacol.40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol.103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series418, 166.
Baden, G. 1989. FASEB J.3, 1807.
Baden, D.G., et al. 1988. Toxicon26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol.30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc.108, 514.
Nakanishi, K. 1985. Toxicon23, 473.
Baden, D.G., et al. 1982. Toxicon19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol.19, 345.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330
• 예방조치 성명서: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable