219415

Cathepsin Inhibitor I

The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): Cathepsin Inhibitor I, Z-FG-NHO-Bz, CATI -1
• 실험식(Hill 표기법): C₂₆H₂₅N₃O₆
• Molecular Weight: 475.49
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: >90% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated; protect from light
• 색상: white
• solubility: DMSO: soluble; acetonitrile: soluble; ethanol: soluble
• 배송 상태: ambient
• 저장 온도: 10-30°C

설명

일반 설명

Cell-permeable cysteine protease inhibitor. Inhibits cathepsin B (k₂/K_i = 8.9 x 10³ M^-1 sec^-1), cathepsin L (k₂/K_i = 3.8 x 10⁵ M^-1 sec^-1), cathepsin S (k₂/K_i = 4.2 x 10⁴ M^-1 sec^-1), and papain (k₂/K_i = 2.4 x 10³ M^-1 sec^-1).

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 8.9 x 10³ M^-1sec^-1), cathepsin L (k₂/K_i = 3.8 x 10⁵ M^-1sec^-1), cathepsin S (k₂/K_i = 4.2 x 10⁴ M^-1sec^-1), and papain (k₂/K_i = 2.4 x 10³ M^-1sec^-1). Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).

Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

k₂/K_i = 8.9 x 10³ M⁻¹sec⁻¹ for cathepsin B

경고

Toxicity: Standard Handling (A)

서열

Z-Phe-Gly-NHO-Bz

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Zhu, D. and Uckun, F.M. 2000. Clin. Cancer Res.6, 2064.
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable