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Merck
모든 사진(1)

문서

400046

Sigma-Aldrich

Hydroxyurea

≥98% (HPLC), solid, RNR inhibitor, Calbiochem

동의어(들):

Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

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About This Item

실험식(Hill 표기법):
CH4N2O2
CAS Number:
Molecular Weight:
76.05
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77

product name

Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Quality Level

분석

≥98% (HPLC)

형태

solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze

색상

white

solubility

water: 5 mg/mL

배송 상태

ambient

저장 온도

2-8°C

InChI

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

InChI key

VSNHCAURESNICA-UHFFFAOYSA-N

일반 설명

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

생화학적/생리학적 작용

Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no

경고

Toxicity: Carcinogenic / Teratogenic (D)

재구성

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

기타 정보

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

Health hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Muta. 1B - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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