474705

Mevastatin, Sodium Salt

Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.

• 동의어(들): Mevastatin, Sodium Salt
• 실험식(Hill 표기법): C₂₃H₃₅O₆ · Na
• Molecular Weight: 430.51
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: ethanol: 20 mg/mL; DMSO: 30 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays.

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays. Mevastatin is an antibiotic that acts as a potent inhibitor of HMG-CoA reductase. Suppresses Ras farnesylation and inhibits myoblast fusion. Causes cell cycle arrest in late G₁ phase. Mevastatin may also induce bone morphogenic protein-2 (BMP-2).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
HMG-CoA reductase

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun.271, 88.
Endo, A. 1992. J. Lipid Res.33, 1569.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable