5.06073

Glutaminase Inhibitor, Compound 968

InSolution, ≥99%, A cell-permeable benzophenanthridinone compound

• 동의어(들): InSolution Glutaminase Inhibitor, Compound 968, GAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I, 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
• 실험식(Hill 표기법): C₂₇H₂₇BrN₂O
• Molecular Weight: 475.42
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 저장 온도: −70°C

설명

일반 설명

A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC₅₀ ≤ 10 µM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
mitochondrial glutaminase

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

물리적 형태

A 10 mM (5 mg/1.05 ml) sterile-filtered solution of Glutaminase Inhibitor, Compound 968 (Cat. No. 352010) in DMSO.

재구성

Following initial thaw slight warming may be required to resolubilize. Aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

기타 정보

Wang, J.B., et al. 2010. Cancer Cell18, 207.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F - (refers to pure substance)
• Flash Point (°C): 87 °C - (refers to pure substance)