SML0601

BPTES

≥95% (HPLC), powder, glutaminase GLS1 (KGA) inhibitor

• 동의어(들): Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide
• 실험식(Hill 표기법): C₂₄H₂₄N₆O₂S₃
• CAS Number: 314045-39-1
• Molecular Weight: 524.68
• MDL number: MFCD01079848
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825569
• NACRES: NA.77

속성

• 제품명: BPTES, ≥95% (HPLC)
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(CC1=CC=CC=C1)NC2=NN=C(S2)CCSCCC3=NN=C(NC(CC4=CC=CC=C4)=O)S3
• InChI: 1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)
• InChI key: MDJIPXYRSZHCFS-UHFFFAOYSA-N

설명

애플리케이션

Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor.

생화학적/생리학적 작용

BPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. Glutaminase converts glutamine to glutamate, which is an important excitatory neurotransmitter in brain and can be further oxidized to α-ketoglutarate to feed the tricarboxylic acid (TCA) cycle and to glutathione, which is important for controlling the level of reactive oxygen species (ROS), particularly important for cancer cell growth. BPTES was found to slow growth of glioma cells. BPTES is a noncompetitive inhibitor with a Ki of 3 μM.

BPTES is a selective inhibitor of Glutaminase GLS1.

Vaccinia virus (VACV) requires glutamine metabolism for its optimal replication. Inhibition of glutaminolysis by bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) can be a potential method to treat poxvirus infections.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable