D2141

6-Diazo-5-oxo-L-norleucine

>95% (TLC), suitable for ligand binding assays

• 동의어(들): (S)-2-Amino-6-diazo-5-oxocaproic acid, DON
• 실험식(Hill 표기법): C₆H₉N₃O₃
• CAS Number: 157-03-9
• Molecular Weight: 171.15
• Beilstein: 1725815
• MDL number: MFCD00037218
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24893639
• NACRES: NA.26

속성

• product name: 6-Diazo-5-oxo-L-norleucine, crystalline
• 분석: >95% (TLC)
• Quality Level: 200
• 형태: crystalline
• 기술: ligand binding assay: suitable
• 색상: light yellow
• mp: 145 °C
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
• InChI: 1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
• InChI key: YCWQAMGASJSUIP-YFKPBYRVSA-N

설명

일반 설명

Chemical structure: amino acid derivatives

애플리케이션

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

생화학적/생리학적 작용

6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.

DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.

DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301 + H311 + H331
• 예방조치 성명서: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges